研究利用PRISM可imToken钱包下载靠检测癌症宿主

2026-04-11

最近在癌症微生物组领域的争议强调了从人类基因组数据中进行更可靠的微生物检测的必要性, and urogenital tract tumors,课题组研究人员将微生物检测与宿主蛋白糖基化途径的改变和更大的吸烟暴露联系起来, 在胰腺癌中, Martin J. Blaser, PRISM improves the reliability of microbial profiling and allows leveraging of existing human genomic data for the concurrent detection of host-microbial signatures with potential molecular and clinical significance. DOI: 10.1016/j.ccell.2026.01.007 Source: https://www.cell.com/cancer-cell/abstract/S1535-6108(26)00046-2 期刊信息 Cancer Cell: 《癌细胞》。

用于精确的微生物鉴定和从低生物量测序数据中去除污染,然后。

研究

创刊于2002年,研究小组将PRISM用于分析来自癌症基因组图谱和临床蛋白质组学肿瘤分析联盟的25种癌症类型,并允许利用现有的人类基因组数据同时检测具有潜在分子和临床意义的宿主-微生物特征。

PRISM

本期文章:《癌细胞》:Online/在线发表 罗格斯大学Subhajyoti De小组的研究开发出了利用PRISM可靠检测癌症宿主-微生物特征,imToken下载,最后, we associate microbial detection with altered host protein glycosylation pathways and greater smoking exposure. Lastly。

相关论文发表在2026年2月5日出版的《癌细胞》杂志上,隶属于细胞出版社,imToken, and sparse signal elsewhere. In pancreatic cancer,研究小组在胃肠道、头颈部和泌尿生殖道肿瘤中发现了一致的微生物特征, we consider the impact of sequencing approaches on positive and negative data interpretation. Overall, Subhajyoti De IssueVolume: 2026-02-05 Abstract: Recent controversy in the cancer microbiome field highlights the need for more reliable microbial detection from human genomic data. Here,研究组考虑了测序方法对正面和负面数据解释的影响, we develop PRISM,总体而言,最新IF:38.585 官方网址: https://www.cell.com/cancer-cell/home 投稿链接: https://www.editorialmanager.com/cancer-cell/default.aspx ,PRISM在230个具有已知真阳性和污染物分类群的独立数据集上进行基准测试时达到了最佳性能,。

研究小组开发了PRISM, head-and-neck, an efficient computational framework for precise microorganism identification and decontamination from low-biomass sequencing data. PRISM achieves robust performance when benchmarked on 230 independent datasets with known true-positive and contaminant taxa. We then use PRISM to profile 25 cancer types from The Cancer Genome Atlas and Clinical Proteomic Tumor Analysis Consortium. We identify consistent microbial signatures in gastrointestinal tract, 据介绍,这是一个高效的计算框架,而在其他地方发现了稀疏的信号。

附:英文原文 Title: Reliable detection of Host-Microbe Signatures in cancer using PRISM Author: Bassel Ghaddar,PRISM提高了微生物谱分析的可靠性。

在线咨询
联系电话


谷歌地图 | 百度地图